The Terpinolene Caryophyllene Myrcene terpene profile supports dopamine & noradrenaline levels, regulates dopamine, and promotes GABA/serotonin activity. Read on to learn how these effects can change your response to stress.
According to a 2018 study published in the Journal of Pharmacy and Pharmacology, the pain-reducing effects of terpinolene can be attributed in-part to influences on endorphin receptors . Increasing endorphins indirectly raises dopamine levels, which may promote motivation & focus.
Caryophyllene has the potential to regulate dopamine activity by rescuing dopaminergic neurons from oxidative stress, a hallmark of many substance use disorders. According to a recent review by the College of Medicine, UAE, caryophyllene may have applications for addressing addictions and some types of depression . Caryophyllene is also a α2-adrenergic receptor agonist, which inhibits the release of noradrenaline . This makes caryophyllene a potential candidate for addressing hypertension.
Many cannabis cultivars with high amounts of terpinolene will also have a considerable amount of ocimene. And while ocimene is not known to directly affect any specific neurotransmitter system, it has been shown in lab studies to have anti-oxidant and anti-inflammatory properties . This actually bodes well for the ‘effect profile’ of TCM, since dopaminergic neurons are especially susceptible to damage from oxidative stress.
If you’re lucky enough to find the TCM profile with a decent amount of myrcene (some terpinolene-dominant cultivars produce only a modest amount), then you could be feeling relaxed & content by the time the effects of terpinolene wear off. If you decided to put that boost of dopamine to good use, you just might be ready to chill & unwind anyway.