Skip to content
SEG logo

supplements

Supplement details

Agmatine

Endorphinergic. involved in the synthesis or activation of endorphins.

endorphin white
augmentor

noon
(noon to mid-afternoon)

afternoon
(mid-afternoon to sunset)

Summary

"Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis...Agmatine binds to α2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones. Treatment with exogenous agmatine exerts neuroprotective effects in animal models of neurotrauma."

“Agmatine - Wikidoc.” Wikidoc.org, 2012, www.wikidoc.org/index.php/Agmatine.

Benefits
1.
May reduce craving symptoms from alcohol withdrawal by upregulating endorphin release [4]
2.
May improve symptoms of burnout by increasing endorphin activity [1]
3.
May reduce symptoms of acute depression caused by neuroinflammation and glutamate dysregulation [1]
Deficiency Factors
Synergies
Applications
Alcohol Detox, Burnout
Dosage Guidelines
Dosing Range
500
-
1500
mg
Dose Increment
500
mg
Maximum Daily
3000
mg
Best absorbed
without food
Recommended Products

See a list of verified product recommendations for Agmatine when you signup for a support plan.

add to supplement stack
add to supplement stack
1. 
Haroon, Ebrahim, et al. “Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders.” Neuropsychopharmacology, vol. 42, no. 1, 15 Sept. 2016, pp. 193–215, www.ncbi.nlm.nih.gov/pmc/articles/PMC5143501/, 10.1038/npp.2016.199.
2. 
Shopsin, Baron. “The Clinical Antidepressant Effect of Exogenous Agmatine Is Not Reversed by Parachlorophenylalanine: A Pilot Study.” Acta Neuropsychiatrica, vol. 25, no. 2, 26 Feb. 2013, pp. 113–118, www.cambridge.org/core/journals/acta-neuropsychiatrica/article/abs/clinical-antidepressant-effect-of-exogenous-agmatine-is-not-reversed-by-parachlorophenylalanine-a-pilot-study/62BA83527CFA2D1F283A4899307103DE, 10.1111/j.1601-5215.2012.00675.x.
3. 
Chang, Chin-Hong, et al. “Increase of β-Endorphin Secretion by Agmatine Is Induced by Activation of Imidazoline I2A Receptors in Adrenal Gland of Rats.” Neuroscience Letters, vol. 468, no. 3, Jan. 2010, pp. 297–299, pubmed.ncbi.nlm.nih.gov/19913596/, 10.1016/j.neulet.2009.11.018.
4. 
Taksande, Brijesh G., et al. “Agmatine Inhibits Behavioral Sensitization to Ethanol through Imidazoline Receptors.” Alcoholism: Clinical and Experimental Research, vol. 43, no. 4, 6 Mar. 2019, pp. 747–757, onlinelibrary.wiley.com/doi/abs/10.1111/acer.13972, 10.1111/acer.13972.
5. 
Mohseni, Gholmreza, et al. “Agmatine Enhances the Antidepressant-like Effect of Lithium in Mouse Forced Swimming Test through NMDA Pathway.” Biomedicine & Pharmacotherapy, vol. 88, Apr. 2017, pp. 931–938, pubmed.ncbi.nlm.nih.gov/28178624/, 10.1016/j.biopha.2017.01.119.

Redefine Your Response to Stress

Avoid the pitfalls of managing stress the ways most people do. Discover a reliable solution to overcome anxiety, depression, and burnout.

Learn More

Accelerate Your Results


Get consistent results, avoid common mistakes, and gain valuable feedback to make your experience fun & rewarding.

Learn More

Johnathan Kobé
Founder - DREAM BIG
Welcome to DREAM BIG! Learn how you can overcome anxiety, depression, & burnout with cannabis & natural supplements.
Johnathan Kobé
Founder - DREAM BIG
Welcome to DREAM BIG! Learn how you can overcome anxiety, depression, & burnout with cannabis & natural supplements.
Use this checklist to guide your journey.
Member Checklist
Schedule Added!

Refresh the page to see your selection in the auxiliary schedule. Use the time-of-day tabs to navigate between schedules.


Warning: Invalid argument supplied for foreach() in /home/853001.cloudwaysapps.com/chwaffxvje/public_html/wp-content/plugins/jupiterx-core/includes/extensions/raven/includes/base/base-widget.php on line 97
Refresh

Membership required

Signup to create your supplement stack and so much more...
  • Print, filter, and view items by time-of-day.
  • Discover powerful supplement combinations.

The supplement market is full of fake & diluted products. Save time & money by only ordering supplements verified for accuracy & potency.

  • Save time with recommended products, and more...
Learn More