Skip to content
SEG logo

supplements

Supplement details

Agmatine

Endorphinergic. involved in the synthesis or activation of endorphins.

endorphin white
augmentor

noon
(noon to mid-afternoon)

afternoon
(mid-afternoon to sunset)

Summary

"Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis...Agmatine binds to α2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones. Treatment with exogenous agmatine exerts neuroprotective effects in animal models of neurotrauma."

“Agmatine - Wikidoc.” Wikidoc.org, 2012, www.wikidoc.org/index.php/Agmatine.

Benefits
1.
May reduce craving symptoms from alcohol withdrawal by upregulating endorphin release [4]
2.
May improve symptoms of burnout by increasing endorphin activity [1]
3.
May reduce symptoms of acute depression caused by neuroinflammation and glutamate dysregulation [1]
Deficiency Factors
Synergies
Applications
Alcohol Detox, Burnout
Dosage Guidelines
Dosing Range
500
-
1500
mg
Dose Increment
500
mg
Maximum Daily
3000
mg
Best absorbed
without food
Recommended Products

See a list of verified product recommendations for Agmatine when you signup for a support plan.

1. 
Haroon, Ebrahim, et al. “Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders.” Neuropsychopharmacology, vol. 42, no. 1, 15 Sept. 2016, pp. 193–215, www.ncbi.nlm.nih.gov/pmc/articles/PMC5143501/, 10.1038/npp.2016.199.
2. 
Shopsin, Baron. “The Clinical Antidepressant Effect of Exogenous Agmatine Is Not Reversed by Parachlorophenylalanine: A Pilot Study.” Acta Neuropsychiatrica, vol. 25, no. 2, 26 Feb. 2013, pp. 113–118, www.cambridge.org/core/journals/acta-neuropsychiatrica/article/abs/clinical-antidepressant-effect-of-exogenous-agmatine-is-not-reversed-by-parachlorophenylalanine-a-pilot-study/62BA83527CFA2D1F283A4899307103DE, 10.1111/j.1601-5215.2012.00675.x.
3. 
Chang, Chin-Hong, et al. “Increase of β-Endorphin Secretion by Agmatine Is Induced by Activation of Imidazoline I2A Receptors in Adrenal Gland of Rats.” Neuroscience Letters, vol. 468, no. 3, Jan. 2010, pp. 297–299, pubmed.ncbi.nlm.nih.gov/19913596/, 10.1016/j.neulet.2009.11.018.
4. 
Taksande, Brijesh G., et al. “Agmatine Inhibits Behavioral Sensitization to Ethanol through Imidazoline Receptors.” Alcoholism: Clinical and Experimental Research, vol. 43, no. 4, 6 Mar. 2019, pp. 747–757, onlinelibrary.wiley.com/doi/abs/10.1111/acer.13972, 10.1111/acer.13972.
5. 
Mohseni, Gholmreza, et al. “Agmatine Enhances the Antidepressant-like Effect of Lithium in Mouse Forced Swimming Test through NMDA Pathway.” Biomedicine & Pharmacotherapy, vol. 88, Apr. 2017, pp. 931–938, pubmed.ncbi.nlm.nih.gov/28178624/, 10.1016/j.biopha.2017.01.119.

Redefine Your Response to Stress

Avoid the pitfalls of managing stress the ways most people do. Discover a reliable solution to overcome anxiety, depression, and burnout.

Learn More

Which type of cannabis is right for you?


Discover cannabis with effects you can rely on for more energy, focus, and creativity. Find out which type is right for you.

Learn More

Johnathan Kobé
Founder - DREAM BIG
Welcome to DREAM BIG! Learn how you can overcome anxiety, depression, & burnout with cannabis & natural supplements.
Johnathan Kobé
Founder - DREAM BIG
Welcome to DREAM BIG! Learn how you can overcome anxiety, depression, & burnout with cannabis & natural supplements.
Attend a DREAM BIG Event
Use coupon code UBER22 at checkout.
Get a free Uber voucher when you sign up!
Get the team experience of building your business
Schedule Added!

Refresh the page to see your selection in the auxiliary schedule. Use the time-of-day tabs to navigate between schedules.


Warning: Invalid argument supplied for foreach() in /home/853001.cloudwaysapps.com/chwaffxvje/public_html/wp-content/plugins/jupiterx-core/includes/extensions/raven/includes/base/base-widget.php on line 97

Membership required

Signup to create your supplement stack and so much more...