Skip to content
SEG logo


Supplement details


Dopaminergic. involved in the synthesis or activation of dopamine.


Noradrenergic. involved in the synthesis or activation of noradrenaline.


Serotonergic. involved in the production or activation of serotonin.


Methylation inhibitor

(noon to mid-afternoon)

(sunset to bedtime)


"Levomefolic acid (INN, also known as L-5-MTHFL-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine...The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by dihydrofolate reductase (DHFR) to become biologically active."

“Levomefolic Acid.” Wikipedia, Wikimedia Foundation, 28 Feb. 2022,


may reduce symptoms of anxiety caused by overmethylation [1]
supports cardiovascular health by reducing homocysteine levels [2]
Deficiency Factors

Access a list of other supplements that enhance the benefits of Methylfolate when you signup for a support plan.

Applications & Precautions
Taking methylfolate can lead to vitamin B12 deficiency. Consider 'preloading' B12 before taking any folate supplement regularly. [1]

5-MTHF is contraindicated for individuals with symptoms of undermethylation.

Increasing dose amount incrementally is generally recommended to avoid side effects.
Dosage Guidelines
Dosing Range
Dose Increment
Maximum Daily
Best absorbed
with food
Recommended Products

See a list of verified product recommendations for Methylfolate when you signup for a support plan.

SCOTT, J. “THE METHYL FOLATE TRAP a Physiological Response in Man to Prevent Methyl Group Deficiency in Kwashiorkor (Methionine Deficiency) and an Explanation for Folic-Acid-Induced Exacerbation of Subacute Combined Degeneration in Pernicious Anaemia.” The Lancet, vol. 318, no. 8242, Aug. 1981, pp. 337–340,, 10.1016/s0140-6736(81)90650-4.
“Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease.” New England Journal of Medicine, vol. 354, no. 15, 13 Apr. 2006, pp. 1567–1577,, 10.1056/nejmoa060900. Accessed 24 Aug. 2021.
“L-Methylfolate Dosage.”,, 2021, Accessed 24 Aug. 2021.

Redefine Your Response to Stress

Avoid the pitfalls of managing stress the ways most people do. Discover a reliable solution to overcome anxiety, depression, and burnout.

Learn More

Which type of cannabis is right for you?

Discover cannabis with effects you can rely on for more energy, focus, and creativity. Find out which type is right for you.

Learn More

Johnathan Kobé
Founder - DREAM BIG
Welcome to DREAM BIG! Learn how you can overcome anxiety, depression, & burnout with cannabis & natural supplements.
Johnathan Kobé
Founder - DREAM BIG
Welcome to DREAM BIG! Learn how you can overcome anxiety, depression, & burnout with cannabis & natural supplements.
Attend a DREAM BIG Event
Use coupon code UBER22 at checkout.
Get a free Uber voucher when you sign up!
Get the team experience of building your business
Schedule Added!

Refresh the page to see your selection in the auxiliary schedule. Use the time-of-day tabs to navigate between schedules.

Warning: Invalid argument supplied for foreach() in /home/ on line 97

Membership required

Signup to create your supplement stack and so much more...