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GABA

GABAnergic. involved in the production or activation of GABA.

gabanergic
precursor

noon
(noon to mid-afternoon)

afternoon
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Summary

"γ-Aminobutyric acid (gamma-aminobutyric acid) or GABA is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. Its principal role is reducing neuronal excitability throughout the nervous system.

GABA is sold as a dietary supplement in many countries. It has been traditionally thought that exogenous GABA doesn't cross the blood-brain barrier, however data obtained from more current research describes the notion as being unclear pending further research."

“γ-Aminobutyric Acid.” Wikipedia, Wikimedia Foundation, 21 Apr. 2022, en.wikipedia.org/wiki/%CE%93-Aminobutyric_acid.

Benefits
1.
Increases systemic GABA levels, which may increase levels in the brain [3]
2.
May improve sleep continuity as well as the time it takes to fall back to sleep [2]
Deficiency Factors
caffeine consumption, dietary insufficiency

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Applications & Precautions
Important Notes
While previous research has suggested that GABA supplements do not readily cross the blood-brain-barrier, more recent research has shown that exogenous GABA may actually increase GABA in the brain. [3]
Dosage Guidelines
Dosing Range
500
-
1000
mg
Dose Increment
500
mg
Maximum Daily
mg
Best absorbed
without food
Recommended Products

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1. 
Steenbergen, Laura, et al. “γ-Aminobutyric Acid (GABA) Administration Improves Action Selection Processes: A Randomised Controlled Trial.” Scientific Reports, vol. 5, no. 1, 31 July 2015, pubmed.ncbi.nlm.nih.gov/26227783/, 10.1038/srep12770.
2. 
Hepsomali, Piril, et al. “Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.” Frontiers in Neuroscience, vol. 14, 17 Sept. 2020, www.frontiersin.org/articles/10.3389/fnins.2020.00923/full, 10.3389/fnins.2020.00923.
3. 
Boonstra, Evert, et al. “Neurotransmitters as Food Supplements: The Effects of GABA on Brain and Behavior.” Frontiers in Psychology, vol. 6, 6 Oct. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4594160/, 10.3389/fpsyg.2015.01520.

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Welcome to DREAM BIG! Learn how you can overcome anxiety, depression, & burnout with cannabis & natural supplements.
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