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Supplement details

Huperzine A

Cholinergic. involved in the synthesis or activation of  acetylcholine.

cholinergic
augmentor

rising
(sunrise to mid-morning)

Summary

"Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata...Huperzine A inhibits the breakdown of the neurotransmitter acetylcholine by the enzyme acetylcholinesterase. It is commonly available over the counter as a nutrient supplement, and is marketed as a cognitive enhancer for improving memory and concentration."

“Huperzine A.” Wikipedia, Wikimedia Foundation, 1 Sept. 2021, en.wikipedia.org/wiki/Huperzine_A.

Benefits
1.
increases levels of acetylcholine by inhibiting the enzyme acetylcholinesterase [1][3]
2.
may alleviate symptoms of some forms of depression by inhibiting NMDA receptor activity [2]
Deficiency Factors

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Applications & Precautions
Precautions
With an exceptionally long half-life, Huperzine A can easily reach toxic levels that may result in nervousness, headache, and muscle twitching. Always take Huperzine A in the morning (to avoid sleep degradation) and follow manufacturer dosing guidelines.
Dosage Guidelines
Dosing Range
100
-
200
mcg
Dose Increment
100
mcg
Maximum Daily
400
mcg
Best absorbed
without food
Recommended Products

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1. 
LIANG, Yan-qi, and Xi-can TANG. “Comparative Studies of Huperzine A, Donepezil, and Rivastigmine on Brain Acetylcholine, Dopamine, Norepinephrine, and 5-Hydroxytryptamine Levels in Freely-Moving Rats.” Acta Pharmacologica Sinica, vol. 27, no. 9, Sept. 2006, pp. 1127–1136, pubmed.ncbi.nlm.nih.gov/16923332/, 10.1111/j.1745-7254.2006.00411.x.
2. 
Zhang, J.-M, and G.-Y Hu. “Huperzine A, a Nootropic Alkaloid, Inhibits N-Methyl-D-Aspartate-Induced Current in Rat Dissociated Hippocampal Neurons.” Neuroscience, vol. 105, no. 3, Aug. 2001, pp. 663–669, pubmed.ncbi.nlm.nih.gov/11516831/, 10.1016/s0306-4522(01)00206-8.
3. 
Wang, Rui, and Xi Can Tang. “Neuroprotective Effects of Huperzine A.” Neurosignals, vol. 14, no. 1-2, 2005, pp. 71–82, www.karger.com/Article/Abstract/85387, 10.1159/000085387.

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