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Lithium Orotate
 

GABAnergic. involved in the production or activation of GABA.

gabanergic
augmentor
Summary

"Lithium orotate (C5H3LiN2O4), is a salt of orotic acid and lithium... It is marketed as a dietary supplement, though it has been researched minimally between 1973–1986 to treat certain medical conditions, such as alcoholism[2] and Alzheimer's disease."

“Lithium Orotate.” Wikipedia, Wikimedia Foundation, 19 Feb. 2022, en.wikipedia.org/wiki/Lithium_orotate.

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Benefits
1.
may reduce feelings of mania by inhibiting the release of dopamine [1]
2.
may reduce agitation associated with depression by increasing GABA activity and inhibiting glutamate transmission [1]
3.
neuroprotective and neuroproliferative for several brain regions related to depression [2]
Deficiency Factors
dietary insufficiency

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Applications & Precautions
Important Notes
While lithium toxicity is possible, the dosage required is only feasible with prescription-only forms.
Dosage Guidelines
Dosing Range
5
-
10
mg
Dose Increment
5
mg
Maximum Daily
30
mg
Best absorbed
with food
Recommended Products

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add to supplement stack
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1. 
Malhi, Gin S., et al. “Potential Mechanisms of Action of Lithium in Bipolar Disorder.” CNS Drugs, vol. 27, no. 2, Feb. 2013, pp. 135–153, link.springer.com/article/10.1007/s40263-013-0039-0, 10.1007/s40263-013-0039-0.
2. 
Schloesser, Robert J, et al. “Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder.” Neuropsychopharmacology, vol. 33, no. 1, 3 Oct. 2007, pp. 110–133, www.nature.com/articles/1301575, 10.1038/sj.npp.1301575.
3. 
Menegas, Samira, et al. “Efficacy of Folic Acid as an Adjunct to Lithium Therapy on Manic-like Behaviors, Oxidative Stress and Inflammatory Parameters in an Animal Model of Mania.” Metabolic Brain Disease, vol. 35, no. 2, 15 Dec. 2019, pp. 413–425, pubmed.ncbi.nlm.nih.gov/31840201/, 10.1007/s11011-019-00503-3.
4. 
Schrauzer, Gerhard N., et al. “Lithium in Scalp Hair of Adults, Students, and Violent Criminals.” Biological Trace Element Research, vol. 34, no. 2, Aug. 1992, pp. 161–176, pubmed.ncbi.nlm.nih.gov/1381936/, 10.1007/bf02785244.
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

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Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.