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Magnesium

GABAnergic. involved in the production or activation of GABA.

gabanergic

Serotonergic. involved in the production or activation of serotonin.

serotoneric
cofactor

noon
(noon to mid-afternoon)

evening
(sunset to bedtime)

Summary
Benefits
1.
potentiates the response of GABA receptors in the brain [1] [3]
2.
promotes neuronal regeneration by increasing BDNF [2]
3.
Supports synthesis of multiple neurotransmitters by serving as a cofactor in related enzymatic processes [4]
4.
Promotes serotonergic transmission by potentiating serotonin receptors [4]
Deficiency Factors
alcohol consumption, caffeine consumption, sugar consumption

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Dosage Guidelines
Dosing Range
-
mg
Dose Increment
mg
Maximum Daily
mg
Best absorbed
without food
Recommended Products

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1. 
Möykkynen, Tommi, et al. “Magnesium Potentiation of the Function of Native and Recombinant GABAA Receptors.” Neuroreport, vol. 12, no. 10, July 2001, pp. 2175–2179, pubmed.ncbi.nlm.nih.gov/11447329/, 10.1097/00001756-200107200-00026.
2. 
Slutsky, Inna, et al. “Enhancement of Learning and Memory by Elevating Brain Magnesium.” Neuron, vol. 65, no. 2, Jan. 2010, pp. 165–177, www.sciencedirect.com/science/article/pii/S0896627309010447, 10.1016/j.neuron.2009.12.026.
3. 
Poleszak E. “Benzodiazepine/GABA(A) Receptors Are Involved in Magnesium-Induced Anxiolytic-like Behavior in Mice.” Pharmacological Reports : PR, vol. 60, no. 4, 2018, pubmed.ncbi.nlm.nih.gov/18799816/.
4. 
Cuciureanu, Magdalena D, and Robert Vink. “Magnesium and Stress.” Nih.gov, University of Adelaide Press, 2020, www.ncbi.nlm.nih.gov/books/NBK507250/.

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