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Zinc

GABAnergic. involved in the production or activation of GABA.

gabanergic

Serotonergic. involved in the production or activation of serotonin.

serotoneric
cofactor

noon
(noon to mid-afternoon)

evening
(sunset to bedtime)

Summary
Benefits
1.
increases the density of serotonergic receptors in the hippocampus [1]
2.
increases systemic noradrenaline levels [1]
3.
supports the metabolism of vitamin B6, an essential cofactor in the synthesis of serotonin [2]
4.
increases levels of GABA in the hippocampus [3]
Deficiency Factors
alcohol consumption, vegan diet, vegetarian diet

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Applications & Precautions
Precautions
Excessive zinc supplementation may result in copper deficiency, which may inhibit dopamine synthesis.

Taking iron supplements concurrently may inhibit the absorption of zinc.
Dosage Guidelines
Dosing Range
-
mg
Dose Increment
mg
Maximum Daily
mg
Best absorbed
with food
Recommended Products

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1. 
Doboszewska, Urszula, et al. “Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity.” Neural Plasticity, vol. 2017, 2017, pp. 1–18, www.ncbi.nlm.nih.gov/pmc/articles/PMC5337390/, 10.1155/2017/3682752. Accessed 31 Aug. 2021.
2. 
“ZINC and the REGULATION of VITAMIN B6 METABOLISM.” Nutrition Reviews, vol. 48, no. 6, 27 Apr. 2009, pp. 255–258, academic.oup.com/nutritionreviews/article-abstract/48/6/255/1930579?redirectedFrom=PDF, 10.1111/j.1753-4887.1990.tb02951.x. Accessed 31 Aug. 2021.
3. 
Takeda, Atsushi, et al. “Differential Effects of Zinc on Glutamatergic and GABAergic Neurotransmitter Systems in the Hippocampus.” Journal of Neuroscience Research, vol. 75, no. 2, 15 Jan. 2004, pp. 225–229, pubmed.ncbi.nlm.nih.gov/14705143/, 10.1002/jnr.10846. Accessed 31 Aug. 2021.

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